Night has fallen upon the Smithsonian Institution in Washington, DC. The guides have gone home, the lights are out, the school kids are tucked in their beds, yet something incredible is stirring as former night guard Larry Daley finds himself lured into his biggest, most imagination-boggling adventure yet in which history truly comes alive. In this second installment of the Night at the Museum saga, Larry faces a battle so epic it could only unfold in the corridors of the world's largest museum. Now, Larry must try to save his formerly inanimate friends from what could be their last stand amid the wonders of the Smithsonian, all of which, from the famous paintings on the walls to the rocket ships in the halls, suddenly have a mind of their own.