After his father's death in the late 1940s, 24-year-old aspiring writer Sal Paradise meets 20-year-old ex-jailbird Dean Moriarty and his beautiful wife Marylou in New York. Dean is extremely charming and has a flexible moral code, and is as fascinated by Sal's obsession with writing as Sal is by the unfettered freedom of his lifestyle. The two men spend intense nights of drinking, dreaming of another world and forming a friendship that will take them on a trip across America. After staying at Bull Lee's place in Louisiana, Sal, Dean, and Marylou continue traveling-naked and utterly enjoying themselves.